Hairless: the ignored antagonist of the Notch signalling pathway
نویسندگان
چکیده
منابع مشابه
The Notch signalling pathway in hair growth
The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role. We report intricate expression patterns for the Notch-1 receptor and three ligands, ...
متن کاملNotch pathway: Making sense of Suppressor of Hairless
Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.
متن کاملThe role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis
Suppressor of Hairless (Su(H)) codes for a protein that interacts with the intracellular domain of Notch to activate the target genes of the Delta-Notch signalling pathway. We have cloned the zebrafish homologue of Su(H) and have analysed its function by morpholino mediated knockdown. While there are at least four notch and four delta homologues in zebrafish, there appears to be only one comple...
متن کاملConservation of the Notch signalling pathway in mammalian neurogenesis.
The Notch pathway functions in multiple cell fate determination processes in invertebrate embryos, including the decision between the neuroblast and epidermoblast lineages in Drosophila. In the mouse, targeted mutation of the Notch pathway genes Notch1 and RBP-Jk has demonstrated a role for these genes in somite segmentation, but a function in neurogenesis and in cell fate decisions has not bee...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2006
ISSN: 0018-0661
DOI: 10.1111/j.2007.0018-0661.01971.x